The anime has a fantasy-parody saga of all time. Dizzying adventure company of hunters on their fifth point, headed sorceress Lina inverse cheerful, will not you get bored for a minute.
The series alternates between serious fights and quests to save the world and silly slapstick humor.
There is one Cross Dressing episode per season, and they will sometimes take breaks in the middle of grave story arcs or fights for semi-plot-related silliness. It manages to find a nice balance, and is one of the must-see series for Medieval European Fantasy.