The anime relates of Yoshika Miyafuji's story, a Fuso witch whose passion to find out about her lost father's destiny ultimately leads her to unite the fight opposing the Neuroi and take in what being a "Strike Witch" means.
Year 1939. That's when humanity faced with a previously unknown enemy. Suddenly, there were those who later would be called "Neuroi". But one thing was known for sure - they began an all-out war against the people. To oppose them, humanity has invented a new type of weapon.