In wanting to resurrect their mother, Edward and Alphonse Elric are forbidden to use a technique in the field of alchemy: human transmutation.
But the experiment goes wrong: Edward loses an arm and a leg and Alphonse's body, his spirit is trapped in armor. Become a State Alchemist, Edward, nicknamed "full metal alchemist", launches, with the help of his brother in search of the Philosopher's Stone, their only chance to regain their original state. They begin to investigate a strange man, "the founder" that passes for a miracle ...